研究業績
原著論文
[2024]
(55)
Otani H, Nakazato R, Ijaz F, Koike K, Ikegami K*
Excessive F-Actin and Microtubule Formation Mediates Primary Cilia Shortening and Loss in Response to Increased Extracellular Osmotic Pressure
BioRxiv doi:10.1101/2024.01.25.577175
54.
Baba K, Uemura K, Nakazato R, Ijaz F, Takahashi S, Ikegami K*
Δ3-tubulin impairs mitotic spindle morphology and increases nuclear size in pancreatic cancer cells
Medical Molecular Morphology 57: 59-67, 2024
[2023]
53.
Nakazato R*, Matsuda Y, Ijaz F, Ikegami K*
Circadian oscillation in primary cilium length by clock genes regulate fibroblast cell migration
EMBO reports 24: e56870, 2023
52.
Ping Y, Ohata K, Kikushima K, Sakamoto T, Islam A, Xu L, Zhang H, Chen B, Yan J, Eto F, Nakane C, Takao K, Miyakawa T, Kabashima K, Watanabe M, Kahyo T, Yao I, Fukuda A, Ikegami K, Konishi Y, Setou M
Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate Glutamate Concentration in the Mice Brain
Biomolecules 13: 784, 2023
[2022]
51.
Ijaz F, Nakazato R, Setou M, Ikegami K*
A pair of primers facing at the double-strand break site enables to detect NHEJ-mediated indel mutations at a 1-bp resolution
Scientific Reports 12: 11681, 2022
50.
Katsumata M, Fujisawa T, Kamiya Y, Tanaka Y, Kamiya C, Inoue Y, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Maekawa M, Setou M, Watanabe H, Ikegami K, Suda T
Effects of long-acting muscarinic antagonists on promoting ciliary function in airway epithelium
BMC Pulmonary Medicine 22: 186, 2022
49.
Sakamoto N*, Aoyama H, Ikegami K
Double-layered two-directional somatopleural cell migration during chicken body wall development revealed with local fluorescent tissue labeling
Anatomical Science International 95: 380-390, 2022
[2021]
48.
Ijaz F, Ikegami K*
Knock-in of labeled proteins into 5’UTR enables highly efficient generation of stable cell lines
Cell Structure and Function 46: 21-35, 2021
[2020]
47.
Kamiya Y, Fujisawa T, Katsumata M, Yasui H, Suzuki Y, Karayama M, Hozumi H, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Setou M, Ito M, Suzuki T, Ikegami K, Suda T
Influenza A virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium
Respiratory Research 21: 282, 2020
46.
Lan H, Suzuki H, Nagatake T, Hosomi K, Ikegami K, Setou M, Kunisawa J
Impaired mucociliary motility enhances antigen-specific nasal IgA immune responses to a cholera toxin-based nasal vaccine
International Immunology 32: 559-568, 2020
45.
Furuhashi S, Sakaguchi T, Murakami T, Fukushima M, Morita Y, Ikegami K, Kikuchi H, Setou M, Takeuchi H
Tenascin C in the Tumor-Nerve Microenvironment Enhances Perineural Invasion and Correlates With Locoregional Recurrence in Pancreatic Ductal Adenocarcinoma
Pancreas 49: 442-454, 2020
44.
Takeuchi K, Xu Y, Kitano M, Chiyonobu K, Abo M, Ikegami K, Ogawa S, Ikejiri M, Kondo M, Gotoh S, Nagao M, Fujisawa T, Nakatani K
Copy number variation in DRC1 is the major cause of primary ciliary dyskinesia in the Japanese population
Molecular Genetics & Genomic Medicine 8: e1137, 2020
[2019]
43.
Matsutani K, Ikegami K, Aoyama H
An in vitro model of region-specific rib formation in chick axial skeleton: Intercellular interaction between somite and lateral plate cells
Mechanisms of Development 159: 103568, 2019
42.
Sato T, Horikawa M, Takei S, Yamazaki F, Ito TK, Kondo T, Sakurai T, Kahyo T, Ikegami K, Sato S, Sato R, Jinno Y, Kawano H, Naoe S, Arita M, Kashiwagi Y, Setou M
Preferential Incorporation of Administered Eicosapentaenoic Acid Into Thin-Cap Atherosclerotic Plaques
Arteriosclerosis, Thrombosis, and Vascular Biology 39: 1802-1816, 2019
[2018]
41.
Katoh TA, Ikegami K, Uchida N, Iwase T, Nakane D, Masaike T, Setou M, Nishizaka T
Three-dimensional tracking of microbeads attached to the tip of single isolated tracheal cilia beating under external load
Scientific Reports 8: 15562, 2018
40.
Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K
UBL3 modification influences protein sorting to small extracellular vesicles
Nature Communications 9: 3936, 2018
39.
Takeda M, Sakaguchi T, Hiraide T, Shibasaki Y, Morita Y, Kikuchi H, Ikegami K, Setou M, Konno H, Takeuchi H
Role of caveolin-1 in hepatocellular carcinoma arising from non-alcoholic fatty liver disease
Cancer Science 109: 2401-2411, 2018
38.
Kimura Y, Tsutsumi K, Konno A, Ikegami K, Hameed S, Kaneko T, Kaplan OI, Teramoto T, Fujiwara M, Ishihara T, Blacque OE, Setou M
Environmental responsiveness of tubulin glutamylation in sensory cilia is regulated by the p38 MAPK pathway
Scientific Reports 8: 8392, 2018
[2018/3月以前]
37.
Shibasaki Y, Horikawa M, Ikegami K, Kiuchi R, Takeda M, Hiraide T, Morita Y, Konno H, Takeuchi H, Setou M, Sakaguchi T
Stearate-to-palmitate ratio modulates endoplasmic reticulum stress and cell apoptosis in non-B non-C hepatoma cells
Cancer Science 109: 1110-1120, 2018
36.
Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, Kunisawa J
Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice
Scientific Reports 8: 2904, 2018
35.
Takeuchi K, Kitano M, Kiyotoshi H, Ikegami K, Ogawa S, Ikejiri M, Nagao M, Fujisawa T, Nakatani K
A targeted next-generation sequencing panel reveals novel mutations in Japanese patients with primary ciliary dyskinesia
Auris Nasus Larynx 45: 585-591, 2018
34.
Ijaz F, Hatanaka Y, Hatanaka T, Tsutsumi K, Iwaki T, Umemura K, Ikegami K*, Setou M*
Proper cytoskeletal architecture beneath the plasma membrane of red blood cells requires Ttll4
Molecular Biology of the Cell 28: 535-544, 2017
33.
Phua SC*, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Setou M, Rohatgi R, Reiter JF, Ikegami K*, Inoue T*
Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision
Cell 168: 264-279, 2017
32.
Vu HT, Akatsu H, Hashizume Y, Setou M*, Ikegami K*
Increase in α-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer’s disease
Scientific Reports 7: 40205, 2017
31.
Hiraide T, Ikegami K, Sakaguchi T, Morita Y, Hayasaka T, Masaki N, Waki M, Sugiyama E, Shinriki S, Takeda M, Shibasaki Y, Miyazaki S, Kikuchi H, Okuyama H, Inoue M, Setou M, Konno H
Accumulation of arachidonic acid-containing phosphatidylinositol at the outer edge of colorectal cancer
Scientific Reports 6: 29935, 2016
30.
Konno A, Ikegami K, Konishi Y, Yang HJ, Abe M, Yamazaki M, Sakimura K, Yao I, Shiba K, Inaba K, Setou M
Ttll9-/- mice sperm flagella show shortening of doublet 7, reduction of doublet 5 polyglutamylation and a stall in beating
Journal of Cell Science 129: 2757-2766, 2016
29.
Iwata T, Ito I, Niimi A, Ikegami K, Marumo S, Tanabe N, Nakaji H, Kanemitsu Y, Matsumoto H, Kamei J, Setou M, Mishima M
Mechanical Stimulation by Postnasal Drip Evokes Cough
PLoS One 10: e0141823, 2015
28.
Hameed S, Ikegami K, Sugiyama E, Matsushita S, Kimura Y, Hayasaka T, Sugiura Y, Masaki N, Waki M, Ohta I, Hossen MA, Setou M
Direct profiling of the phospholipid composition of adult Caenorhabditis elegans using whole-body imaging mass spectrometry
Analytical and Bioanalytical Chemistry 407: 7589-7602, 2015
27.
Hayasaka T, Goto-Inoue N, Masaki N, Ikegami K, Setou M
Application of 2,5-dihydroxyacetophenone with sublimation provides efficient ionization of lipid species by atmospheric pressure matrix-assisted laser desorption/ionization imaging mass spectrometry
Surface and Interface Analysis 46: 1219-1222, 2014
26.
Waki M, Ide Y, Ishizaki I, Nagata Y, Masaki N, Sugiyama E, Kurabe N, Nicolaescu D, Yamazaki F, Hayasaka T, Ikegami K, Kondo T, Shibata K, Hiraide T, Taki Y, Ogura H, Shiiya N, Sanada N, Setou M
Single-cell time-of-flight secondary ion mass spectrometry reveals that human breast cancer stem cells have significantly lower content of palmitoleic acid compared to their counterpart non-stem cancer cells
Biochimie 107: 73-77, 2014
25.
Ide Y, Waki M, Ishizaki I, Nagata Y, Yamazaki F, Hayasaka T, Masaki N, Ikegami K, Kondo T, Shibata K, Ogura H, Sanada N, Setou M
Single cell lipidomics of SKBR-3 breast cancer cells by using time-of-flight secondary-ion mass spectrometry
Surface and Interface Analysis 46: 181-184, 2014
24.
Berezniuk I, Lyons PJ, Sironi JJ, Xiao H, Setou M, Angeletti RH, Ikegami K, Fricker LD
Cytosolic carboxypeptidase 5 removes α- and γ-linked glutamates from tubulin
The Journal of Biological Chemistry 288: 30445-30453, 2013
23.
Morita Y, Sakaguchi T, Ikegami K, Goto-Inoue N, Hayasaka T, Hang VT, Tanaka H, Harada T, Shibasaki Y, Suzuki A, Fukumoto K, Inaba K, Murakami M, Setou M, Konno H
Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression
Journal of Hepatology 59: 292-299, 2013
22.
Tanaka H, Zaima N, Sasaki T, Hayasaka T, Goto-Inoue N, Onoue K, Ikegami K, Morita Y, Yamamoto N, Mano Y, Sano M, Saito T, Sato K, Konno H, Setou M, Unno N
Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm
PLoS One 8: e57398, 2013
21.
Berezniuk I, Vu HT, Lyons PJ, Sironi JJ, Xiao H, Burd B, Setou M, Angeletti RH, Ikegami K*, Fricker LD*
Cytosolic Carboxypeptidase 1 Is Involved in Processing α- and β-Tubulin
The Journal of Biological Chemistry 287: 6503-6517, 2012
20.
Yang HJ, Sugiura Y, Ikegami K, Konishi Y, Setou M
Axonal Gradient of Arachidonic Acid-containing Phosphatidylcholine and Its Dependence on Actin Dynamics
The Journal of Biological Chemistry 287: 5290-5300, 2012
19.
Lee JE, Silhavy JL, Zaki MS, Schroth J, Bielas SL, Marsh SE, Olvera J, Brancati F, Iannicelli M, Ikegami K, Schlossman AM, Merriman B, Attie-Bitach T, Logan CV, Glass IA, Cluckey A, Louie CM, Lee JH, Raynes HR, Rapin I, Castroviejo IP, Setou M, Barbot C, Boltshauser E, Nelson SF, Hildebrandt F, Johnson CA, Doherty DA, Valente EM, Gleeson JG
CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium
Nature Genetics 44: 193-199, 2012
18.
Asakawa H, Ikegami K, Setou M, Watanabe N, Tsukada M, Fukuma T
Submolecular-scale imaging of α-helices and C-terminal domains of tubulins by frequency modulation atomic force microscopy in liquid
Biophysical Journal 101: 1270-1276 , 2011
17.
Yang HJ, Sugiura Y, Ishizaki I, Sanada N, Ikegami K, Zaima N, Shrivas K, Setou M
Imaging of lipids in cultured mammalian neurons by matrix assisted laser/desorption ionization and secondary ion mass spectrometry
Surface and Interface Analysis 42: 1606-1611, 2010
16.
Yang HJ, Ishizaki I, Sanada N, Zaima N, Sugiura Y, Yao I, Ikegami K, Setou M
Detection of characteristic distributions of phospholipid head groups and fatty acids on neurite surface by time-of-flight secondary ion mass spectrometry
Medical Molecular Morphology 43: 158-164, 2010
15.
Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song SY, Matsuno A, Mizutani A, Sawabe M, Chao MV, Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M
SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals
PLoS One 5: e11755, 2010
14.
Kimura Y, Kurabe N, Ikegami K, Tsutsumi K, Konishi Y, Kaplan OI, Kunitomo H, Iino Y, Blacque OE, Setou M
Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs)
The Journal of biological chemistry 285: 22936-22941, 2010
13.
Ikegami K*, Sato S, Nakamura K, Ostrowski LE, Setou M*
Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry
Proceedings of the National Academy of Sciences of the United States of America 107: 10490-10495, 2010
12.
Morita Y, Ikegami K, Goto-Inoue N, Hayasaka T, Zaima N, Tanaka H, Uehara T, Setoguchi T, Sakaguchi T, Igarashi H, Sugimura H, Setou M, Konno H
Imaging mass spectrometry of gastric carcinoma in formalin-fixed paraffin-embedded tissue microarray
Cancer science 101: 267-273, 2010
11.
Ikegami K, Setou M
TTLL10 can perform tubulin glycylation when co-expressed with TTLL8
FEBS Letters 583: 1957-1963, 2009
10.
Mukai M, Ikegami K, Sugiura Y, Takeshita K, Nakagawa A, Setou M
Recombinant mammalian tubulin polyglutamylase TTLL7 performs both initiation and elongation of polyglutamylation on beta-tubulin through a random sequential pathway
Biochemistry 48: 1084-1093, 2009
9.
Yamada MK, Konishi Y, Kakinoki B, Ikegami K, Setou M
Enhancement of Trk signaling pathways by the cholestane amide conjugate MCC-257
Journal of pharmacological sciences 108: 131-134, 2008
8.
Yang H, Takagi H, Konishi Y, Ageta H, Ikegami K, Yao I, Sato S, Hatanaka K, Inokuchi K, Seog DH, Setou M
Transmembrane and ubiquitin-like domain-containing protein 1 (Tmub1/HOPS) facilitates surface expression of GluR2-containing AMPA receptors
PloS One 3: e2809, 2008
7.
Ikegami K, Horigome D, Mukai M, Livnat I, MacGregor GR, Setou M
TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1
FEBS Letters 582: 1129-1134, 2008
6.
Ikegami K, Heier RL, Taruishi M, Takagi H, Mukai M, Shimma S, Taira S, Hatanaka K, Morone N, Yao I, Campbell PK, Yuasa S, Janke C, Macgregor GR, Setou M
Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function
Proceedings of the National Academy of Sciences of the United States of America 104: 3213-3218, 2007
5.
Hatanaka K, Ikegami K, Takagi H, Setou M
Hypo-osmotic shock induces nuclear export and proteasome-dependent decrease of UBL5
Biochemical and biophysical research communications 350: 610-615, 2006
4.
Ikegami K, Mukai M, Tsuchida J, Heier RL, Macgregor GR, Setou M
TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites
The Journal of Biological Chemistry 281: 30707-30716, 2006
3.
Ikegami K, Kato S, Koike T
N-alpha-p-tosyl-L-lysine chloromethyl ketone (TLCK) suppresses neuritic degeneration caused by different experimental paradigms including in vitro Wallerian degeneration
Brain research 1030: 81-93, 2004
2.
Ikegami K, Koike T
Non-apoptotic neurite degeneration in apoptotic neuronal death: pivotal role of mitochondrial function in neurites
Neuroscience 122: 617-626, 2003
1.
Ikegami K, Koike T
Membrane depolarization-mediated survival of sympathetic neurons occurs through both phosphatidylinositol 3-kinase- and CaM kinase II-dependent pathways
Brain research 866: 218-226, 2000